NPCs, monsters, and debilities

Monsters and NPCs don't mark debilities, and player-facing moves never allow PCs to inflict them on NPCs or monsters. Monsters and most NPCs don't roll for moves, so suffering disadvantage on two stats doesn't make any sense.

So: if a monster suffers an effect that would leave them weakened, they don't mark weakened—you just describe them as being slower or shaky. Maybe you offer the PCs an opportunity as a result?

Followers can trigger player moves. If you want, assign a debility to a follower as a temporary tag (weakened, dazed, or miserable), imposing disadvantage on any relevant rolls. But mostly, you should reflect a follower's current state in how you portray them, and how they act, and what they're capable of or willing to do.